Downtown LA is shaping up as a great beer destination. Far Bar in Little Tokyo, Public School 612 plus the yearly Craft Beer Crawl put on by the Beer Chicks.
Another addition to check out is the Buzz Wine & Beer Store on the corner of 5th Street & Spring Street.
From what they have posted on their website, they have a good mix of imports and California beers as well as a few others.
I will scout it out in the future and give a further report then.